GlutaredoxinV1, Main, Exploration, bibRecord, 000277

Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy.

Identifieur interne : 000277 ( Main/Exploration ); précédent : 000276; suivant : 000278

Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy.

Auteurs : Shashank Masaldan [Australie] ; Sharnel A S. Clatworthy [Australie] ; Cristina Gamell [Australie] ; Zoe M. Smith [Australie] ; Paul S. Francis [Australie] ; Delphine Denoyer [Australie] ; Peter M. Meggyesy [Australie] ; Sharon La Fontaine [Australie] ; Michael A. Cater [Australie]

Source :

Redox biology [ 2213-2317 ] ; 2018.

RBID : pubmed:29579719

Descripteurs français

KwdFr :
- Animaux (MeSH), Autophagie (génétique), Cellules épithéliales (métabolisme), Cuivre (métabolisme), Fibroblastes (métabolisme), Glutarédoxines (génétique), Glutathion (génétique), Homéostasie (MeSH), Humains (MeSH), Lysosomes (métabolisme), Mâle (MeSH), Prostate (métabolisme), Souris (MeSH), Superoxide dismutase-1 (génétique), Transporteurs de cations (génétique), Vieillissement de la cellule (génétique).
MESH :
- génétique : Autophagie, Glutarédoxines, Glutathion, Superoxide dismutase-1, Transporteurs de cations, Vieillissement de la cellule.
- métabolisme : Cellules épithéliales, Cuivre, Fibroblastes, Lysosomes, Prostate.
- Animaux, Homéostasie, Humains, Mâle, Souris.

English descriptors

KwdEn :
- Animals (MeSH), Autophagy (genetics), Cation Transport Proteins (genetics), Cellular Senescence (genetics), Copper (metabolism), Copper Transporter 1 (MeSH), Copper-Transporting ATPases (genetics), Copper-Transporting ATPases (metabolism), Epithelial Cells (metabolism), Fibroblasts (metabolism), Glutaredoxins (genetics), Glutathione (genetics), Homeostasis (MeSH), Humans (MeSH), Lysosomes (metabolism), Male (MeSH), Mice (MeSH), Prostate (metabolism), Superoxide Dismutase-1 (genetics).
MESH :
- chemical , genetics : Cation Transport Proteins, Copper-Transporting ATPases, Glutaredoxins, Glutathione, Superoxide Dismutase-1.
- genetics : Autophagy, Cellular Senescence.
- chemical , metabolism : Copper, Copper-Transporting ATPases, Epithelial Cells, Fibroblasts, Lysosomes, Prostate.
- Animals, Copper Transporter 1, Homeostasis, Humans, Male, Mice.

Abstract

Cellular senescence is characterized by irreversible growth arrest incurred through either replicative exhaustion or by pro-oncogenic cellular stressors (radioactivity, oxidative stress, oncogenic activation). The enrichment of senescent cells in tissues with age has been associated with tissue dyshomeostasis and age-related pathologies including cancers, neurodegenerative disorders (e.g. Alzheimer's, Parkinson's, etc.) and metabolic disorders (e.g. diabetes). We identified copper accumulation as being a universal feature of senescent cells [mouse embryonic fibroblasts (MEF), human prostate epithelial cells and human diploid fibroblasts] in vitro. Elevated copper in senescent MEFs was accompanied by elevated levels of high-affinity copper uptake protein 1 (Ctr1), diminished levels of copper-transporting ATPase 1 (Atp7a) (copper export) and enhanced antioxidant defence reflected by elevated levels of glutathione (GSH), superoxide dismutase 1 (SOD1) and glutaredoxin 1 (Grx1). The levels of intracellular copper were further increased in senescent MEFs cultured in copper supplemented medium and in senescent Mottled Brindled (Mo^br) MEFs lacking functional Atp7a. Finally, we demonstrated that the restoration/preservation of autophagic-lysosomal degradation in senescent MEFs following rapamycin treatment correlated with attenuation of copper accumulation in these cells despite a further decrease in Atp7a levels. This study for the first time establishes a link between Atp7a and the autophagic-lysosomal pathway, and a requirement for both to effect efficient copper export. Such a connection between cellular autophagy and copper homeostasis is significant, as both have emerged as important facets of age-associated degenerative disease.

DOI: 10.1016/j.redox.2018.03.007
PubMed: 29579719
PubMed Central: PMC5953000

Affiliations:

Australie

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Francis, Paul S" sort="Francis, Paul S" uniqKey="Francis P" first="Paul S" last="Francis">Paul S. Francis</name>
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</affiliation>
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<author><name sortKey="Denoyer, Delphine" sort="Denoyer, Delphine" uniqKey="Denoyer D" first="Delphine" last="Denoyer">Delphine Denoyer</name>
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<series><title level="j">Redox biology</title>
<idno type="eISSN">2213-2317</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Autophagy (genetics)</term>
<term>Cation Transport Proteins (genetics)</term>
<term>Cellular Senescence (genetics)</term>
<term>Copper (metabolism)</term>
<term>Copper Transporter 1 (MeSH)</term>
<term>Copper-Transporting ATPases (genetics)</term>
<term>Copper-Transporting ATPases (metabolism)</term>
<term>Epithelial Cells (metabolism)</term>
<term>Fibroblasts (metabolism)</term>
<term>Glutaredoxins (genetics)</term>
<term>Glutathione (genetics)</term>
<term>Homeostasis (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Lysosomes (metabolism)</term>
<term>Male (MeSH)</term>
<term>Mice (MeSH)</term>
<term>Prostate (metabolism)</term>
<term>Superoxide Dismutase-1 (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Autophagie (génétique)</term>
<term>Cellules épithéliales (métabolisme)</term>
<term>Cuivre (métabolisme)</term>
<term>Fibroblastes (métabolisme)</term>
<term>Glutarédoxines (génétique)</term>
<term>Glutathion (génétique)</term>
<term>Homéostasie (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Lysosomes (métabolisme)</term>
<term>Mâle (MeSH)</term>
<term>Prostate (métabolisme)</term>
<term>Souris (MeSH)</term>
<term>Superoxide dismutase-1 (génétique)</term>
<term>Transporteurs de cations (génétique)</term>
<term>Vieillissement de la cellule (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cation Transport Proteins</term>
<term>Copper-Transporting ATPases</term>
<term>Glutaredoxins</term>
<term>Glutathione</term>
<term>Superoxide Dismutase-1</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Autophagy</term>
<term>Cellular Senescence</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Autophagie</term>
<term>Glutarédoxines</term>
<term>Glutathion</term>
<term>Superoxide dismutase-1</term>
<term>Transporteurs de cations</term>
<term>Vieillissement de la cellule</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Copper</term>
<term>Copper-Transporting ATPases</term>
<term>Epithelial Cells</term>
<term>Fibroblasts</term>
<term>Lysosomes</term>
<term>Prostate</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules épithéliales</term>
<term>Cuivre</term>
<term>Fibroblastes</term>
<term>Lysosomes</term>
<term>Prostate</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Copper Transporter 1</term>
<term>Homeostasis</term>
<term>Humans</term>
<term>Male</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Homéostasie</term>
<term>Humains</term>
<term>Mâle</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Cellular senescence is characterized by irreversible growth arrest incurred through either replicative exhaustion or by pro-oncogenic cellular stressors (radioactivity, oxidative stress, oncogenic activation). The enrichment of senescent cells in tissues with age has been associated with tissue dyshomeostasis and age-related pathologies including cancers, neurodegenerative disorders (e.g. Alzheimer's, Parkinson's, etc.) and metabolic disorders (e.g. diabetes). We identified copper accumulation as being a universal feature of senescent cells [mouse embryonic fibroblasts (MEF), human prostate epithelial cells and human diploid fibroblasts] in vitro. Elevated copper in senescent MEFs was accompanied by elevated levels of high-affinity copper uptake protein 1 (Ctr1), diminished levels of copper-transporting ATPase 1 (Atp7a) (copper export) and enhanced antioxidant defence reflected by elevated levels of glutathione (GSH), superoxide dismutase 1 (SOD1) and glutaredoxin 1 (Grx1). The levels of intracellular copper were further increased in senescent MEFs cultured in copper supplemented medium and in senescent Mottled Brindled (Mo<sup>br</sup>
) MEFs lacking functional Atp7a. Finally, we demonstrated that the restoration/preservation of autophagic-lysosomal degradation in senescent MEFs following rapamycin treatment correlated with attenuation of copper accumulation in these cells despite a further decrease in Atp7a levels. This study for the first time establishes a link between Atp7a and the autophagic-lysosomal pathway, and a requirement for both to effect efficient copper export. Such a connection between cellular autophagy and copper homeostasis is significant, as both have emerged as important facets of age-associated degenerative disease.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29579719</PMID>
<DateCompleted><Year>2018</Year>
<Month>10</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2213-2317</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>16</Volume>
<PubDate><Year>2018</Year>
<Month>06</Month>
</PubDate>
</JournalIssue>
<Title>Redox biology</Title>
<ISOAbbreviation>Redox Biol</ISOAbbreviation>
</Journal>
<ArticleTitle>Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy.</ArticleTitle>
<Pagination><MedlinePgn>322-331</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S2213-2317(18)30081-8</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.redox.2018.03.007</ELocationID>
<Abstract><AbstractText>Cellular senescence is characterized by irreversible growth arrest incurred through either replicative exhaustion or by pro-oncogenic cellular stressors (radioactivity, oxidative stress, oncogenic activation). The enrichment of senescent cells in tissues with age has been associated with tissue dyshomeostasis and age-related pathologies including cancers, neurodegenerative disorders (e.g. Alzheimer's, Parkinson's, etc.) and metabolic disorders (e.g. diabetes). We identified copper accumulation as being a universal feature of senescent cells [mouse embryonic fibroblasts (MEF), human prostate epithelial cells and human diploid fibroblasts] in vitro. Elevated copper in senescent MEFs was accompanied by elevated levels of high-affinity copper uptake protein 1 (Ctr1), diminished levels of copper-transporting ATPase 1 (Atp7a) (copper export) and enhanced antioxidant defence reflected by elevated levels of glutathione (GSH), superoxide dismutase 1 (SOD1) and glutaredoxin 1 (Grx1). The levels of intracellular copper were further increased in senescent MEFs cultured in copper supplemented medium and in senescent Mottled Brindled (Mo<sup>br</sup>
) MEFs lacking functional Atp7a. Finally, we demonstrated that the restoration/preservation of autophagic-lysosomal degradation in senescent MEFs following rapamycin treatment correlated with attenuation of copper accumulation in these cells despite a further decrease in Atp7a levels. This study for the first time establishes a link between Atp7a and the autophagic-lysosomal pathway, and a requirement for both to effect efficient copper export. Such a connection between cellular autophagy and copper homeostasis is significant, as both have emerged as important facets of age-associated degenerative disease.</AbstractText>
<CopyrightInformation>Copyright © 2018. Published by Elsevier B.V.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Masaldan</LastName>
<ForeName>Shashank</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, Burwood, Victoria 3125, Australia; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia. Electronic address: shashank.masaldan@florey.edu.au.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Clatworthy</LastName>
<ForeName>Sharnel A S</ForeName>
<Initials>SAS</Initials>
<AffiliationInfo><Affiliation>Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, Burwood, Victoria 3125, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gamell</LastName>
<ForeName>Cristina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smith</LastName>
<ForeName>Zoe M</ForeName>
<Initials>ZM</Initials>
<AffiliationInfo><Affiliation>School of Life and Environmental Sciences, Deakin University, Geelong, Victoria 3220, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Francis</LastName>
<ForeName>Paul S</ForeName>
<Initials>PS</Initials>
<AffiliationInfo><Affiliation>School of Life and Environmental Sciences, Deakin University, Geelong, Victoria 3220, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Denoyer</LastName>
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<ArticleId IdType="pmc">PMC5953000</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Nature. 2016 Feb 11;530(7589):184-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26840489</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Metallomics. 2014 Apr;6(4):793-808</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24522867</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2012 Aug 3;287(32):26678-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22648419</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2008 Aug 28;454(7208):1142-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18650808</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncol Rep. 2013 May;29(5):1805-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23468063</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Age (Dordr). 2013 Dec;35(6):2255-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23576095</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Prog Neurobiol. 2000 Dec;62(6):649-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10880854</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1997 Mar 7;88(5):593-602</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9054499</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1999 Dec 24;274(52):36952-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10601249</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gastroenterology. 2006 Feb;130(2):493-506</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16472602</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Apr 4;278(14):11731-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12551891</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Genet. 1980 Feb;18(1-2):117-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7387619</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2014;13(12 ):1840-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24866342</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biometals. 2014 Aug;27(4):661-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24816595</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Mol Genet. 1997 Jul;6(7):1037-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9215672</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Anal Chem. 2008 Dec 15;80(24):9817-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19072276</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2009;4(3):e4919</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19305496</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2007 Jan 1;21(1):1-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17210783</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Metallomics. 2015 Nov;7(11):1459-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26313539</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2008 Nov 15;7(22):3601-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19001874</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Chem Biol. 2008 Mar;4(3):176-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18277979</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2013 Apr 15;27(8):900-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23599344</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Immunol. 2011 Aug;23 (4):532-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21872769</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1989 Apr 5;264(10):5598-605</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2564391</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2015 Dec;21(12):1424-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26646499</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Analyst. 2011 Jun 21;136(12):2578-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21394377</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oxid Med Cell Longev. 2017;2017:3793817</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28280523</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Mol Genet. 2001 Feb 15;10(4):361-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11157799</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2011 Mar 25;286(12):10073-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21242307</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Mol Genet. 1999 Jun;8(6):1069-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10332039</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Metallomics. 2016 Sep 1;8(9):853-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27339113</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2010 Aug 27;285(35):27111-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20566629</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6842-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11391005</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2009 Dec 4;284(49):33949-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19808669</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2009 Apr;1793(4):605-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19046998</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Cell. 2012 Jun;23(11):2066-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22496421</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1995 Feb 3;270(5):2320-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7836465</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2015 Jan;125(1):25-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25654547</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem J. 2012 Aug 15;446(1):59-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22651090</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Biochem Cell Biol. 2013 Sep;45(9):2087-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23871936</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2006 Apr;1762(4):485-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16488577</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 1963 May;17:299-313</Citation>
<ArticleIdList><ArticleId IdType="pubmed">13985244</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Cell Res. 1996 Nov 25;229(1):7-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8940243</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Aging Cell. 2015 Aug;14(4):644-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25754370</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogene. 2008 May 1;27(20):2801-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18193093</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2016 Jan;22(1):78-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26657143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Aging Cell. 2012 Apr;11(2):345-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22321662</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lab Invest. 2016 Feb;96(2):206-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26367492</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Immunol. 2008 Jul;8(7):512-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18469829</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2013 Nov 21;155(5):1119-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24238961</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Differ. 2009 Jan;16(1):70-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19008921</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Dev Cell. 2014 Jun 23;29(6):686-700</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24909901</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2010 Nov 15;24(22):2463-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21078816</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 1991 Dec;5(12B):2375-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1752433</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Redox Biol. 2018 Apr;14 :100-115</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28888202</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2007 Nov-Dec;3(6):542-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17611390</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Analyst. 2014 May 21;139(10):2416-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24691543</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1181-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17158254</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Nutr. 2005 Dec;135(12):2762-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16317117</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2014 May 22;509(7501):439-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24848057</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Interdiscip Top Gerontol. 2014;39:45-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24862014</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2011 Nov 02;479(7372):232-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22048312</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 1996 Nov 15;15(22):6084-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8947031</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2016 Jun 14;7(24):37064-37080</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27175597</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2005 Jul;1(2):84-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16874052</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogene. 1993 Sep;8(9):2457-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8103211</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2886-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10694572</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Cell Physiol. 2013 Apr 15;304(8):C768-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23426973</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2017 Mar 23;169(1):132-147.e16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28340339</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2012 Jan 20;287(4):2485-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22130675</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Pharmacol. 1997 May 9;53(9):1347-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9214696</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Autophagy. 2017 Jan 2;13(1):99-113</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27791464</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2004 Dec 17;119(6):861-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15607981</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Rapid Commun Mass Spectrom. 2011 Feb 28;25(4):526-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21259361</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Age (Dordr). 2012 Aug;34(4):783-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21695420</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2010 Jun 3;465(7298):645-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20463663</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy.

Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy.

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